Journal:

Article Title: Sensitive analysis of anti-HIV drugs, efavirenz, lopinavir and ritonavir, in human hair by liquid chromatography coupled with tandem mass spectrometry

doi: 10.1002/rcm.3750

Figure Lengend Snippet: Main mass spectrometry parameters for assaying ritonavir, lopinavir and efavirenz

Article Snippet: Efavirenz, lopinavir and ritonavir reference compounds, and internal standards (IS), ritonavir-d6 and celecoxib, were obtained from Toronto Research Chemicals (Toronto, Canada).

Techniques: Mass Spectrometry

Journal:

Article Title: Sensitive analysis of anti-HIV drugs, efavirenz, lopinavir and ritonavir, in human hair by liquid chromatography coupled with tandem mass spectrometry

doi: 10.1002/rcm.3750

Figure Lengend Snippet: Comparison of the extraction methods for assaying lopinavir/ritonavir and efavirenz in samples incurred from human hair. The methanol and enzyme digestion were carried out at 37°C with shaking in a water bath for 14 h. Data are represented by mean ± standard deviation (SD) (n = 4). *p <0.01, compared with cut hair/MeOH by t-test.

Article Snippet: Efavirenz, lopinavir and ritonavir reference compounds, and internal standards (IS), ritonavir-d6 and celecoxib, were obtained from Toronto Research Chemicals (Toronto, Canada).

Techniques: Standard Deviation

Journal:

Article Title: Sensitive analysis of anti-HIV drugs, efavirenz, lopinavir and ritonavir, in human hair by liquid chromatography coupled with tandem mass spectrometry

doi: 10.1002/rcm.3750

Figure Lengend Snippet: Time course for extraction of ritonavir, lopinavir and efavirenz from samples incurred from cut hair (1 mm length segments) in methanol at 37°C with shaking in a water bath. After the methanol extraction, the samples were then subjected to MTBE/EA (1:1) extraction and analyzed by LC/MS/MS. Each point represents mean ± SD (n = 4).

Article Snippet: Efavirenz, lopinavir and ritonavir reference compounds, and internal standards (IS), ritonavir-d6 and celecoxib, were obtained from Toronto Research Chemicals (Toronto, Canada).

Techniques: Liquid Chromatography with Mass Spectroscopy

Journal:

Article Title: Sensitive analysis of anti-HIV drugs, efavirenz, lopinavir and ritonavir, in human hair by liquid chromatography coupled with tandem mass spectrometry

doi: 10.1002/rcm.3750

Figure Lengend Snippet: LC/MS/MS chromatograms for measuring ritonavir and lopinavir in positive ionization MRM mode: (A) blank hair; (B) blank hair spiked with ritonavir/lopinavir at low QC concentration (lopinavir, 0.15 ng/mg, ritonavir, 0.03 ng/mg); and (C) authentic hair sample from a patient on HAART (lopinavir, 3.0 ng/mg, ritonavir, 0.70 ng/mg). The detailed LC/MS/MS conditions are described in the text.

Article Snippet: Efavirenz, lopinavir and ritonavir reference compounds, and internal standards (IS), ritonavir-d6 and celecoxib, were obtained from Toronto Research Chemicals (Toronto, Canada).

Techniques: Liquid Chromatography with Mass Spectroscopy, Concentration Assay

Journal:

Article Title: Sensitive analysis of anti-HIV drugs, efavirenz, lopinavir and ritonavir, in human hair by liquid chromatography coupled with tandem mass spectrometry

doi: 10.1002/rcm.3750

Figure Lengend Snippet: Accuracy and precision for analysis of spiked QC samples and authentic hair QC samples

Article Snippet: Efavirenz, lopinavir and ritonavir reference compounds, and internal standards (IS), ritonavir-d6 and celecoxib, were obtained from Toronto Research Chemicals (Toronto, Canada).

Techniques: Concentration Assay

Journal:

Article Title: Sensitive analysis of anti-HIV drugs, efavirenz, lopinavir and ritonavir, in human hair by liquid chromatography coupled with tandem mass spectrometry

doi: 10.1002/rcm.3750

Figure Lengend Snippet: Matrix factors for analyzing lopinavir, ritonavir and efavirenz in human hair

Article Snippet: Efavirenz, lopinavir and ritonavir reference compounds, and internal standards (IS), ritonavir-d6 and celecoxib, were obtained from Toronto Research Chemicals (Toronto, Canada).

Techniques: